Connor model of Nerve membrane potentials

In 1977 Connor et al showed that crab axons had a fast acting Potassium current which altered their membrane properties. This is usually called IA and its presence means that the nerve axons can sustain slow rates of repetitive firing. It also means that synaptic inputs from nerve cell to nerve cell must supply much more current than in the Hodgkin-Huxley models.

2 cell model

This model is of two cells, whose membrane potentials obey the Connor equations for crab axons. In the model, you can vary the stimulus current for each cell, the kinds of synaptic connection between the two neurons and the strength of the connections. You can also turn off IA, effectively converting the simulation to a Hodgkin-Huxley equations.

The strength of the stimulating current can be adjusted by a slider control from -15 to +50 ľA.

The 2 neurons are connected by a synapse. The user can choose whether the transmitter activates sodium, potassium, or chloride channels in the post-synaptic cell. The user can use a slider to change the strength of the synapse.

Download source and executables

View sample simulation results

A multicell version is available too.

New in V2.12: (current version)
  • updated Web page to reflect change of server
  • bug in settings dialog text amended

New in V2.1:

  • A public domain library (CVODE) has replaced the NAG library used in versions 1 and 2.0. This is both faster and smaller, as well as free!
  • updated help file

New in V2: (archived here)

  • You can switch off the A Current and use a simulation similar to that of Hodkgin-Huxley.
  • You can print the traces directly
  • You can save the data to a plain text file, in addition to the original copy to clipboard
  • updated help file

 


Chris Elliott, 22 Oct 99 (version 2.12)