Parkinsons's disease
Aim: to know cellular basis of CNS diseases

Suggested reading:



Parkinsons disease:

Youdim MBH, Riederer P (1997) Understanding Parkinson's disease. Scientific American, 276, No.1, pp.52-59 (January issue)
Blandini F et al, (2000) Functional changes of the basal ganglia circuitry in Parkinson's disease  Progress in Neurobiology  62: 63-88

Savitt JM et al (2006)  Diagnosis and treatment of Parkinson disease: molecules to medicine J. Clin. Invest. 116:1744-1754  

Wood-Kaczmar, A et al (2006) Understanding the molecular causes of Parkinson's disease   Trends  Mol Med12:521-528

Le W & Appel SH (2004) Mutant genes responsible for Parkinson’s disease Curent Opinion in Pharmacology 4: 79-84

Maguire-Zeaiss, KA et al (2004)  Synuclein, dopamine and oxidative stress: co-conspirators in Parkinson's disease? Molecular Brain Res 134:18-23 

Bonini & Giasson (2005)  Snaring the Function of α-Synuclein Cell 123:359-361
Volpicelli-Daley LA, et al (2011) Exogenous a-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death Neuron, 72:57-71 
Schulz-Schaeffer, WJ (2010) The synaptic pathology of α-synuclein aggregation in dementia with Lewy bodies, Parkinson’s disease and Parkinson’s disease dementia ACTA NEUROPATHOLOGICA  120, 131-143

Cookson MR (2003) Neurodegeneration: How Does Parkin Prevent Parkinson's Disease? Current Biology 13: R522-R524

Dauer, W & Przedborski, S (2003) Parkinson's Disease: Mechanisms and Models Neuron  39: 889-909

Borlongan, CV Sanberg PR (2002) Neural transplantation for treatment of Parkinson's disease  Drug Discovery Today 7:674-682
Winkler C et al (2005) Cell transplantation in Parkinson's disease: how can we make it work? Trends neurosci 28:86-92

Benabid, AL (2003)  Deep brain stimulation for Parkinson's disease  Current Opinion in Neurobiology 13:696-706
Wichmann, T & eLong, M.R. (2006)  Deep Brain Stimulation for Neurologic and Neuropsychiatric Disorders Neuron 52: 197-204
Schiefer TK et al (2011) Moving forward: advances in the treatment of movement disorders with deep brain stimulation Frontiers

Barker, RA (2006) Continuing trials of GDNF in Parkinson's disease  Lancet Neurology 5:285-6
Fiandaca, M (2008) Current status of gene therapy trials for Parkinson's disease Exp neurol 209:51-59

Schapira, AHV (2009) Neurobiology and treatment of Parkinson's disease. Trends Pharm Sci 30:41-47
Bogaerts, V et al (2008)  Genetic findings in Parkinson’s disease and translation into treatment: a leading role for mitochondria? Genes, Brain and Behavior (2008) 7: 129–151
Weaver SM (2009)  Bilateral Deep Brain Stimulation vs Best Medical Therapy for Patients With Advanced Parkinson Disease A Randomized Controlled Trial JAMA. 301:63-73 (you probably want to read the commentary here first)

Obeso, JA et al (2010) Missing pieces in the Parkinson's disease puzzle Nature Medicine 16, 653–661 

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PD and L-DOPA at Youtube
PD and GDNF at youtube

page last updated by Chris Elliott, December 5 dec 2011