Alzheimer's disease

Aim: to know cellular basis of CNS disease

Suggested reading:



Alzheimer's diseaseCitron M (2004) b-Secretase inhibition for the treatment of Alzheimer's disease – promise and challenge Trends Pharm Sci 25:92-97

Verdile G et al (2004) The role of beta amyloid in Alzheimer’s disease: still a cause of everything or the only one who got caught?   Pharmacological Research 50:397-409  

Goedert, M & Spillantini, MG (2006) A Century of Alzheimer's Disease Science 314:777 - 781  

Roberson, ED & Mucke, L (2006) 100 Years and Counting: Prospects for Defeating Alzheimer's Disease Science, 314:781 - 784

Hardy, J (2006) A Hundred Years of Alzheimer's Disease Research Neuron 52:3-13

LaFerla F et al (2007) Intracellular amyloid-bold beta in Alzheimer's disease Nature rev neurosci 8, 499-509

Ballatore, C (2007) Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
Nature Reviews Neuroscience 8, 663-672

St George-Hyslop, PH & Morris, JC (2008) Will anti-amyloid therapies work for Alzheimer's disease? 
Lancet 372:180-182

Wozniak, MA (2008) Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques J pathol 217:131 - 138

Vassar R et al (2009)  The β-Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential  J neurosci 29:12787-12794

Biran Y  et al (2009) Pharmacotherapeutic targets in Alzheimer's disease J Cell Mol Med 13: 61-68

Zatta P (2009) Alzheimer’s disease, metal ions and metal homeostatic therapy Trends pharm Sci 30:346-355

Bu, G (2009) Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy Nature Revi Neurosci 10, 333-344

Carter, MD (2010) The Development of New Therapeutics for Alzheimer's Disease Clinical Pharmacology & Therapeutics 88: 475–486

Web Links

Search for BBC history of the NICE Alzheimer's drugs review in the courts
See commentary at


The powerpoint presentation (for computers) is here

page last updated by Chris Elliott, December 7, 2010