Brain in health and Disease

Lecturer

Title

 Summary

1

CJHE

Introduction to Brain in Health and Disease

Organisation and development of mammalian nervous systems; review of synaptic function and role of main neurotransmitters

2

STS

The Botulinal Toxins

Bungarotoxins, botulinal toxins; toxins as tools in analysis of normal and diseased neurons

3

STS

Saxitoxins and Phospholipase A2 toxins

Saxitoxins block actions potentials and the mechanisms by which they do this will be examined. Snake venom phospholipase A2 toxin blocks synaptic transmission and the mechanism by which it does so has been recently elucidated and will be explored in this lecture.

4

STS

Lysosomal Storage Disease

Neurodegeneration; Lysosomes, variety of LSDs and their symptoms

5

STS

Sensory neuropathy

The causes of Neurodegeneration in sensory systems (e.g. genes, diabetes) will be explored

6

CJHE

Pain

Primary sensory transduction of pain and its modulation by drugs (paracetamol); gate control hypothesis of spinal cord; structural and physiological evidence for this hypothesis; pain and its perception in the brain

7

CJHE

Multiple Sclerosis

Role of glia in health and disease, development of Node of Ranvier, symptoms of MS, inflammatory hypothesis of MS

8

CJHE

Parkinson’s Disease

Symptoms of PD, cellular loss of DA neurons, effect on motor function; environmental and genetic factors leading to PD, treatment

9

CJHE

Alzheimer’s disease

Symptoms of AD, cellular loss of cortical and hippocampal neurons, effect on motor function; environmental and genetic factors leading to AD, proposed treatments


Powerpoints only available on the york.ac.uk network

Page last updated on 19 Oct 2009